Perricone MD Neuropeptide Deep Crease Serum
Perricone MD
$189.00
📦 Shipping Information:
Available from Nordstrom | Free standard shipping on qualifying US orders 
Product Insights & Style Tips
The Perricone MD Neuropeptide Deep Crease Serum feels like clinical luxury in a silky, weightless veil. This highly potent concentrate uses neuropeptides—powerful, protein-like building blocks with a unique chemical structure that supports the skin barrier and hydration—to smooth the look of stubborn lines around the mouth, eyes, lips and forehead. Over time, wrinkle depth appears shallower and the look of expression lines reduced, while skin drinks in moisture for a quiet, refined glow.
After cleansing, massage onto face and neck with a gentle upward motion. Wait until fully absorbed, then follow with your favorite Perricone MD moisturizer. Use morning and evening. The silky texture glides on smoothly, sits without heaviness, and creates a smooth canvas for the day or night routine, targeting marionette lines, frown lines, smile lines and nasolabial folds as you layer with other skincare steps.
Perricone MD leans into peptide science as a signature of skincare intelligence. This Deep Crease Serum stays true to that lineage—highly potent, barrier-supporting, and easy to weave into a daily regimen. Paraben-free, phthalate-free, sulfate-free and Made in the USA, it sits as a quietly luxe anchor in a polished, age-conscious routine.
Materials / Fabrication
- Highly potent, silky serum
- Neuropeptides as key ingredient (protein-like building blocks that support the skin barrier and hydration)
- Smooths lines around the mouth, eyes, lips and forehead, including marionette lines, frown lines, smile lines and nasolabial folds
- Over time, wrinkle depth appears shallower and expression lines reduced
- Size: 1 oz
- Paraben-free; phthalate-free; sulfate-free
- Made in the USA
Recommended Care
- Use morning and evening after cleansing; massage onto face and neck with gentle upward motions; wait until fully absorbed before applying moisturizer
- Patch test before first use
- Avoid contact with eyes; rinse thoroughly if contact occurs
- If irritation occurs, discontinue use
- Store in a cool, dry place away from direct sunlight; keep bottle tightly closed
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About Perricone Md
Perricone MD is a pioneering beauty brand renowned for its science-led approach to skincare, focusing on results-driven products that target visible signs of aging and support overall skin health. Founded by board-certified dermatologist Dr. Nicholas Perricone, the brand blends advanced clinical research with powerful antioxidants and nutrient-rich formulations. Perricone MD’s product range spans moisturizers, cleansers, serums, treatments, and supplements designed to address concerns such as fine lines, uneven texture, loss of firmness, and dullness. The lineup also features specialized anti-aging solutions and no-makeup skincare hybrid makeup, appealing to those who want visible results without harsh ingredients. Perricone MD attracts beauty enthusiasts seeking innovation, dermatologist expertise, and high-performance skincare for radiant, healthier-looking skin.